- •Preface
- •Biological Vision Systems
- •Visual Representations from Paintings to Photographs
- •Computer Vision
- •The Limitations of Standard 2D Images
- •3D Imaging, Analysis and Applications
- •Book Objective and Content
- •Acknowledgements
- •Contents
- •Contributors
- •2.1 Introduction
- •Chapter Outline
- •2.2 An Overview of Passive 3D Imaging Systems
- •2.2.1 Multiple View Approaches
- •2.2.2 Single View Approaches
- •2.3 Camera Modeling
- •2.3.1 Homogeneous Coordinates
- •2.3.2 Perspective Projection Camera Model
- •2.3.2.1 Camera Modeling: The Coordinate Transformation
- •2.3.2.2 Camera Modeling: Perspective Projection
- •2.3.2.3 Camera Modeling: Image Sampling
- •2.3.2.4 Camera Modeling: Concatenating the Projective Mappings
- •2.3.3 Radial Distortion
- •2.4 Camera Calibration
- •2.4.1 Estimation of a Scene-to-Image Planar Homography
- •2.4.2 Basic Calibration
- •2.4.3 Refined Calibration
- •2.4.4 Calibration of a Stereo Rig
- •2.5 Two-View Geometry
- •2.5.1 Epipolar Geometry
- •2.5.2 Essential and Fundamental Matrices
- •2.5.3 The Fundamental Matrix for Pure Translation
- •2.5.4 Computation of the Fundamental Matrix
- •2.5.5 Two Views Separated by a Pure Rotation
- •2.5.6 Two Views of a Planar Scene
- •2.6 Rectification
- •2.6.1 Rectification with Calibration Information
- •2.6.2 Rectification Without Calibration Information
- •2.7 Finding Correspondences
- •2.7.1 Correlation-Based Methods
- •2.7.2 Feature-Based Methods
- •2.8 3D Reconstruction
- •2.8.1 Stereo
- •2.8.1.1 Dense Stereo Matching
- •2.8.1.2 Triangulation
- •2.8.2 Structure from Motion
- •2.9 Passive Multiple-View 3D Imaging Systems
- •2.9.1 Stereo Cameras
- •2.9.2 3D Modeling
- •2.9.3 Mobile Robot Localization and Mapping
- •2.10 Passive Versus Active 3D Imaging Systems
- •2.11 Concluding Remarks
- •2.12 Further Reading
- •2.13 Questions
- •2.14 Exercises
- •References
- •3.1 Introduction
- •3.1.1 Historical Context
- •3.1.2 Basic Measurement Principles
- •3.1.3 Active Triangulation-Based Methods
- •3.1.4 Chapter Outline
- •3.2 Spot Scanners
- •3.2.1 Spot Position Detection
- •3.3 Stripe Scanners
- •3.3.1 Camera Model
- •3.3.2 Sheet-of-Light Projector Model
- •3.3.3 Triangulation for Stripe Scanners
- •3.4 Area-Based Structured Light Systems
- •3.4.1 Gray Code Methods
- •3.4.1.1 Decoding of Binary Fringe-Based Codes
- •3.4.1.2 Advantage of the Gray Code
- •3.4.2 Phase Shift Methods
- •3.4.2.1 Removing the Phase Ambiguity
- •3.4.3 Triangulation for a Structured Light System
- •3.5 System Calibration
- •3.6 Measurement Uncertainty
- •3.6.1 Uncertainty Related to the Phase Shift Algorithm
- •3.6.2 Uncertainty Related to Intrinsic Parameters
- •3.6.3 Uncertainty Related to Extrinsic Parameters
- •3.6.4 Uncertainty as a Design Tool
- •3.7 Experimental Characterization of 3D Imaging Systems
- •3.7.1 Low-Level Characterization
- •3.7.2 System-Level Characterization
- •3.7.3 Characterization of Errors Caused by Surface Properties
- •3.7.4 Application-Based Characterization
- •3.8 Selected Advanced Topics
- •3.8.1 Thin Lens Equation
- •3.8.2 Depth of Field
- •3.8.3 Scheimpflug Condition
- •3.8.4 Speckle and Uncertainty
- •3.8.5 Laser Depth of Field
- •3.8.6 Lateral Resolution
- •3.9 Research Challenges
- •3.10 Concluding Remarks
- •3.11 Further Reading
- •3.12 Questions
- •3.13 Exercises
- •References
- •4.1 Introduction
- •Chapter Outline
- •4.2 Representation of 3D Data
- •4.2.1 Raw Data
- •4.2.1.1 Point Cloud
- •4.2.1.2 Structured Point Cloud
- •4.2.1.3 Depth Maps and Range Images
- •4.2.1.4 Needle map
- •4.2.1.5 Polygon Soup
- •4.2.2 Surface Representations
- •4.2.2.1 Triangular Mesh
- •4.2.2.2 Quadrilateral Mesh
- •4.2.2.3 Subdivision Surfaces
- •4.2.2.4 Morphable Model
- •4.2.2.5 Implicit Surface
- •4.2.2.6 Parametric Surface
- •4.2.2.7 Comparison of Surface Representations
- •4.2.3 Solid-Based Representations
- •4.2.3.1 Voxels
- •4.2.3.3 Binary Space Partitioning
- •4.2.3.4 Constructive Solid Geometry
- •4.2.3.5 Boundary Representations
- •4.2.4 Summary of Solid-Based Representations
- •4.3 Polygon Meshes
- •4.3.1 Mesh Storage
- •4.3.2 Mesh Data Structures
- •4.3.2.1 Halfedge Structure
- •4.4 Subdivision Surfaces
- •4.4.1 Doo-Sabin Scheme
- •4.4.2 Catmull-Clark Scheme
- •4.4.3 Loop Scheme
- •4.5 Local Differential Properties
- •4.5.1 Surface Normals
- •4.5.2 Differential Coordinates and the Mesh Laplacian
- •4.6 Compression and Levels of Detail
- •4.6.1 Mesh Simplification
- •4.6.1.1 Edge Collapse
- •4.6.1.2 Quadric Error Metric
- •4.6.2 QEM Simplification Summary
- •4.6.3 Surface Simplification Results
- •4.7 Visualization
- •4.8 Research Challenges
- •4.9 Concluding Remarks
- •4.10 Further Reading
- •4.11 Questions
- •4.12 Exercises
- •References
- •1.1 Introduction
- •Chapter Outline
- •1.2 A Historical Perspective on 3D Imaging
- •1.2.1 Image Formation and Image Capture
- •1.2.2 Binocular Perception of Depth
- •1.2.3 Stereoscopic Displays
- •1.3 The Development of Computer Vision
- •1.3.1 Further Reading in Computer Vision
- •1.4 Acquisition Techniques for 3D Imaging
- •1.4.1 Passive 3D Imaging
- •1.4.2 Active 3D Imaging
- •1.4.3 Passive Stereo Versus Active Stereo Imaging
- •1.5 Twelve Milestones in 3D Imaging and Shape Analysis
- •1.5.1 Active 3D Imaging: An Early Optical Triangulation System
- •1.5.2 Passive 3D Imaging: An Early Stereo System
- •1.5.3 Passive 3D Imaging: The Essential Matrix
- •1.5.4 Model Fitting: The RANSAC Approach to Feature Correspondence Analysis
- •1.5.5 Active 3D Imaging: Advances in Scanning Geometries
- •1.5.6 3D Registration: Rigid Transformation Estimation from 3D Correspondences
- •1.5.7 3D Registration: Iterative Closest Points
- •1.5.9 3D Local Shape Descriptors: Spin Images
- •1.5.10 Passive 3D Imaging: Flexible Camera Calibration
- •1.5.11 3D Shape Matching: Heat Kernel Signatures
- •1.6 Applications of 3D Imaging
- •1.7 Book Outline
- •1.7.1 Part I: 3D Imaging and Shape Representation
- •1.7.2 Part II: 3D Shape Analysis and Processing
- •1.7.3 Part III: 3D Imaging Applications
- •References
- •5.1 Introduction
- •5.1.1 Applications
- •5.1.2 Chapter Outline
- •5.2 Mathematical Background
- •5.2.1 Differential Geometry
- •5.2.2 Curvature of Two-Dimensional Surfaces
- •5.2.3 Discrete Differential Geometry
- •5.2.4 Diffusion Geometry
- •5.2.5 Discrete Diffusion Geometry
- •5.3 Feature Detectors
- •5.3.1 A Taxonomy
- •5.3.2 Harris 3D
- •5.3.3 Mesh DOG
- •5.3.4 Salient Features
- •5.3.5 Heat Kernel Features
- •5.3.6 Topological Features
- •5.3.7 Maximally Stable Components
- •5.3.8 Benchmarks
- •5.4 Feature Descriptors
- •5.4.1 A Taxonomy
- •5.4.2 Curvature-Based Descriptors (HK and SC)
- •5.4.3 Spin Images
- •5.4.4 Shape Context
- •5.4.5 Integral Volume Descriptor
- •5.4.6 Mesh Histogram of Gradients (HOG)
- •5.4.7 Heat Kernel Signature (HKS)
- •5.4.8 Scale-Invariant Heat Kernel Signature (SI-HKS)
- •5.4.9 Color Heat Kernel Signature (CHKS)
- •5.4.10 Volumetric Heat Kernel Signature (VHKS)
- •5.5 Research Challenges
- •5.6 Conclusions
- •5.7 Further Reading
- •5.8 Questions
- •5.9 Exercises
- •References
- •6.1 Introduction
- •Chapter Outline
- •6.2 Registration of Two Views
- •6.2.1 Problem Statement
- •6.2.2 The Iterative Closest Points (ICP) Algorithm
- •6.2.3 ICP Extensions
- •6.2.3.1 Techniques for Pre-alignment
- •Global Approaches
- •Local Approaches
- •6.2.3.2 Techniques for Improving Speed
- •Subsampling
- •Closest Point Computation
- •Distance Formulation
- •6.2.3.3 Techniques for Improving Accuracy
- •Outlier Rejection
- •Additional Information
- •Probabilistic Methods
- •6.3 Advanced Techniques
- •6.3.1 Registration of More than Two Views
- •Reducing Error Accumulation
- •Automating Registration
- •6.3.2 Registration in Cluttered Scenes
- •Point Signatures
- •Matching Methods
- •6.3.3 Deformable Registration
- •Methods Based on General Optimization Techniques
- •Probabilistic Methods
- •6.3.4 Machine Learning Techniques
- •Improving the Matching
- •Object Detection
- •6.4 Quantitative Performance Evaluation
- •6.5 Case Study 1: Pairwise Alignment with Outlier Rejection
- •6.6 Case Study 2: ICP with Levenberg-Marquardt
- •6.6.1 The LM-ICP Method
- •6.6.2 Computing the Derivatives
- •6.6.3 The Case of Quaternions
- •6.6.4 Summary of the LM-ICP Algorithm
- •6.6.5 Results and Discussion
- •6.7 Case Study 3: Deformable ICP with Levenberg-Marquardt
- •6.7.1 Surface Representation
- •6.7.2 Cost Function
- •Data Term: Global Surface Attraction
- •Data Term: Boundary Attraction
- •Penalty Term: Spatial Smoothness
- •Penalty Term: Temporal Smoothness
- •6.7.3 Minimization Procedure
- •6.7.4 Summary of the Algorithm
- •6.7.5 Experiments
- •6.8 Research Challenges
- •6.9 Concluding Remarks
- •6.10 Further Reading
- •6.11 Questions
- •6.12 Exercises
- •References
- •7.1 Introduction
- •7.1.1 Retrieval and Recognition Evaluation
- •7.1.2 Chapter Outline
- •7.2 Literature Review
- •7.3 3D Shape Retrieval Techniques
- •7.3.1 Depth-Buffer Descriptor
- •7.3.1.1 Computing the 2D Projections
- •7.3.1.2 Obtaining the Feature Vector
- •7.3.1.3 Evaluation
- •7.3.1.4 Complexity Analysis
- •7.3.2 Spin Images for Object Recognition
- •7.3.2.1 Matching
- •7.3.2.2 Evaluation
- •7.3.2.3 Complexity Analysis
- •7.3.3 Salient Spectral Geometric Features
- •7.3.3.1 Feature Points Detection
- •7.3.3.2 Local Descriptors
- •7.3.3.3 Shape Matching
- •7.3.3.4 Evaluation
- •7.3.3.5 Complexity Analysis
- •7.3.4 Heat Kernel Signatures
- •7.3.4.1 Evaluation
- •7.3.4.2 Complexity Analysis
- •7.4 Research Challenges
- •7.5 Concluding Remarks
- •7.6 Further Reading
- •7.7 Questions
- •7.8 Exercises
- •References
- •8.1 Introduction
- •Chapter Outline
- •8.2 3D Face Scan Representation and Visualization
- •8.3 3D Face Datasets
- •8.3.1 FRGC v2 3D Face Dataset
- •8.3.2 The Bosphorus Dataset
- •8.4 3D Face Recognition Evaluation
- •8.4.1 Face Verification
- •8.4.2 Face Identification
- •8.5 Processing Stages in 3D Face Recognition
- •8.5.1 Face Detection and Segmentation
- •8.5.2 Removal of Spikes
- •8.5.3 Filling of Holes and Missing Data
- •8.5.4 Removal of Noise
- •8.5.5 Fiducial Point Localization and Pose Correction
- •8.5.6 Spatial Resampling
- •8.5.7 Feature Extraction on Facial Surfaces
- •8.5.8 Classifiers for 3D Face Matching
- •8.6 ICP-Based 3D Face Recognition
- •8.6.1 ICP Outline
- •8.6.2 A Critical Discussion of ICP
- •8.6.3 A Typical ICP-Based 3D Face Recognition Implementation
- •8.6.4 ICP Variants and Other Surface Registration Approaches
- •8.7 PCA-Based 3D Face Recognition
- •8.7.1 PCA System Training
- •8.7.2 PCA Training Using Singular Value Decomposition
- •8.7.3 PCA Testing
- •8.7.4 PCA Performance
- •8.8 LDA-Based 3D Face Recognition
- •8.8.1 Two-Class LDA
- •8.8.2 LDA with More than Two Classes
- •8.8.3 LDA in High Dimensional 3D Face Spaces
- •8.8.4 LDA Performance
- •8.9 Normals and Curvature in 3D Face Recognition
- •8.9.1 Computing Curvature on a 3D Face Scan
- •8.10 Recent Techniques in 3D Face Recognition
- •8.10.1 3D Face Recognition Using Annotated Face Models (AFM)
- •8.10.2 Local Feature-Based 3D Face Recognition
- •8.10.2.1 Keypoint Detection and Local Feature Matching
- •8.10.2.2 Other Local Feature-Based Methods
- •8.10.3 Expression Modeling for Invariant 3D Face Recognition
- •8.10.3.1 Other Expression Modeling Approaches
- •8.11 Research Challenges
- •8.12 Concluding Remarks
- •8.13 Further Reading
- •8.14 Questions
- •8.15 Exercises
- •References
- •9.1 Introduction
- •Chapter Outline
- •9.2 DEM Generation from Stereoscopic Imagery
- •9.2.1 Stereoscopic DEM Generation: Literature Review
- •9.2.2 Accuracy Evaluation of DEMs
- •9.2.3 An Example of DEM Generation from SPOT-5 Imagery
- •9.3 DEM Generation from InSAR
- •9.3.1 Techniques for DEM Generation from InSAR
- •9.3.1.1 Basic Principle of InSAR in Elevation Measurement
- •9.3.1.2 Processing Stages of DEM Generation from InSAR
- •The Branch-Cut Method of Phase Unwrapping
- •The Least Squares (LS) Method of Phase Unwrapping
- •9.3.2 Accuracy Analysis of DEMs Generated from InSAR
- •9.3.3 Examples of DEM Generation from InSAR
- •9.4 DEM Generation from LIDAR
- •9.4.1 LIDAR Data Acquisition
- •9.4.2 Accuracy, Error Types and Countermeasures
- •9.4.3 LIDAR Interpolation
- •9.4.4 LIDAR Filtering
- •9.4.5 DTM from Statistical Properties of the Point Cloud
- •9.5 Research Challenges
- •9.6 Concluding Remarks
- •9.7 Further Reading
- •9.8 Questions
- •9.9 Exercises
- •References
- •10.1 Introduction
- •10.1.1 Allometric Modeling of Biomass
- •10.1.2 Chapter Outline
- •10.2 Aerial Photo Mensuration
- •10.2.1 Principles of Aerial Photogrammetry
- •10.2.1.1 Geometric Basis of Photogrammetric Measurement
- •10.2.1.2 Ground Control and Direct Georeferencing
- •10.2.2 Tree Height Measurement Using Forest Photogrammetry
- •10.2.2.2 Automated Methods in Forest Photogrammetry
- •10.3 Airborne Laser Scanning
- •10.3.1 Principles of Airborne Laser Scanning
- •10.3.1.1 Lidar-Based Measurement of Terrain and Canopy Surfaces
- •10.3.2 Individual Tree-Level Measurement Using Lidar
- •10.3.2.1 Automated Individual Tree Measurement Using Lidar
- •10.3.3 Area-Based Approach to Estimating Biomass with Lidar
- •10.4 Future Developments
- •10.5 Concluding Remarks
- •10.6 Further Reading
- •10.7 Questions
- •References
- •11.1 Introduction
- •Chapter Outline
- •11.2 Volumetric Data Acquisition
- •11.2.1 Computed Tomography
- •11.2.1.1 Characteristics of 3D CT Data
- •11.2.2 Positron Emission Tomography (PET)
- •11.2.2.1 Characteristics of 3D PET Data
- •Relaxation
- •11.2.3.1 Characteristics of the 3D MRI Data
- •Image Quality and Artifacts
- •11.2.4 Summary
- •11.3 Surface Extraction and Volumetric Visualization
- •11.3.1 Surface Extraction
- •Example: Curvatures and Geometric Tools
- •11.3.2 Volume Rendering
- •11.3.3 Summary
- •11.4 Volumetric Image Registration
- •11.4.1 A Hierarchy of Transformations
- •11.4.1.1 Rigid Body Transformation
- •11.4.1.2 Similarity Transformations and Anisotropic Scaling
- •11.4.1.3 Affine Transformations
- •11.4.1.4 Perspective Transformations
- •11.4.1.5 Non-rigid Transformations
- •11.4.2 Points and Features Used for the Registration
- •11.4.2.1 Landmark Features
- •11.4.2.2 Surface-Based Registration
- •11.4.2.3 Intensity-Based Registration
- •11.4.3 Registration Optimization
- •11.4.3.1 Estimation of Registration Errors
- •11.4.4 Summary
- •11.5 Segmentation
- •11.5.1 Semi-automatic Methods
- •11.5.1.1 Thresholding
- •11.5.1.2 Region Growing
- •11.5.1.3 Deformable Models
- •Snakes
- •Balloons
- •11.5.2 Fully Automatic Methods
- •11.5.2.1 Atlas-Based Segmentation
- •11.5.2.2 Statistical Shape Modeling and Analysis
- •11.5.3 Summary
- •11.6 Diffusion Imaging: An Illustration of a Full Pipeline
- •11.6.1 From Scalar Images to Tensors
- •11.6.2 From Tensor Image to Information
- •11.6.3 Summary
- •11.7 Applications
- •11.7.1 Diagnosis and Morphometry
- •11.7.2 Simulation and Training
- •11.7.3 Surgical Planning and Guidance
- •11.7.4 Summary
- •11.8 Concluding Remarks
- •11.9 Research Challenges
- •11.10 Further Reading
- •Data Acquisition
- •Surface Extraction
- •Volume Registration
- •Segmentation
- •Diffusion Imaging
- •Software
- •11.11 Questions
- •11.12 Exercises
- •References
- •Index
11 3D Medical Imaging |
457 |
Fig. 11.8 A skull surface extracted from a CT image showing typical staircase artifacts. These can be reduced by smoothing the surface or by blurring the 3D image before applying marching cubes. This latter approach is often better
(the corners of a cube). This could provide 256 potential cases, but by adjusting for rotational and other symmetries these can be reduced to 15 cases. Ambiguities in 3D, if not dealt with correctly, can lead to holes in the resulting surface. There are a number of possible solutions to this, for example using tetrahedra rather than cubes.
Volumetric medical images usually do not have resolutions of comparable quality to what is achieved with range data. Partly as a consequence of this, surface extraction algorithms such as marching cubes [47] may produce surfaces with typical ‘staircase’ effects. Further processing may smooth the surface or decimate it. It is often better to smooth the 3D volume before running marching cubes as this reduces the noise in the dataset. As mentioned above, the triangulation can contain singularities (zero angled triangles), holes, duplicate triangles, folds and so on, if the implementation is not robust.
Example: Curvatures and Geometric Tools Once the surface has been extracted, different operations are possible for medical imaging applications. We will illustrate briefly with the example of curvatures. Curvatures are an intuitive quantity but, since they involve second derivatives, they tend to be very sensitive to surface irregularities [6, 7] They can be used as a quantification of the surface or as a tool to evolve the surface [5]. Figure 11.9 shows some illustrative examples.
11.3.2 Volume Rendering
It is also possible to produce a rendering of the anatomy from a model without extracting a surface first. This method is known as volume rendering. The idea originated in computer graphics before its application to medical imaging, but this method is ideally suited to rendering of volumetric data such as CT or MRI scans. A volume rendering of a CT image is shown in Fig. 11.10. The idea is very similar to
458 |
P.G. Batchelor et al. |
Fig. 11.9 (a) Colon image colored by curvature. The colon is deformed by a curvature (‘Ricci’) flow into a cylinder, from which comparisons can be made [69]. (b) Mean curvature of the cortical surface. These are used to quantify the folding of the cortex, as a biomarker of brain shape [6]
raytracing, in that a ray is cast from a given 2D image pixel through the volume. The process aims to simulate the passage of light through a semi-transparent medium. If the ray has a current color Crn, as it passes through a voxel v with color Cv and opacity αv , the color of the ray is changed using the over operator:
r |
= |
(1 |
− |
r |
+ |
|
(11.2) |
Cn+1 |
|
|
αv )Cn |
|
αv Cv . |
The scalar values in the image need to be mapped to color and opacity by the transfer function, which determines the color and opacity of a voxel depending on the greyscale values in the image (i.e. Cv (I ) and αv (I ) are functions of the image intensity, I ). There are some simple transfer functions, such as the maximum intensity projection, which just calculates the maximum value along the ray. This has proven useful in viewing vessels in angiography images.
It is also possible to composite the rays back to front rather than front to back, in which case the slightly different under operator is used:
|
|
αn+1 |
= |
αn |
+ |
α |
v |
1 |
− |
αn |
|
|||
|
|
r |
|
|
r |
|
|
r |
(11.3) |
|||||
|
|
ˆ r |
|
|
= |
ˆ r |
+ ˆ v |
|
|
− r |
|
|||
|
|
Cn+1 |
|
Cn |
|
C |
1 |
|
αn , |
|
||||
where C |
C |
α |
C |
v . There are numerous implementation issues with |
||||||||||
ˆ r = αr Cr and |
ˆ v = |
v |
|
volume rendering and many tricks to speed up the process. Even on modern graphics cards and CPUs, however, the interactivity of volume rendering is not the same as surface rendering. A common option is to display the volume rendered scene at a lower resolution during interaction and display the full image only when interaction stops. This will become less of a problem as graphics performance increases.
In general, to achieve a good result, it is necessary to roughly segment the organ of interest first before performing surface or volume rendering. In the next section
11 3D Medical Imaging |
459 |
Fig. 11.10 A volume rendering of the CT image from Fig. 11.8. There is smoothing of the skull surface, and we are able to view this through the transparent skin
we will look at the problem of segmentation. A further issue is how to incorporate a lighting model into volume rendering. In the volumetric lighting approach, a normal is calculated at each voxel from finite difference approximation of the scalar gradient:
|
|
|
∂I |
|
I (x+ x,y,z)−I (x− x,y,z) |
|
|
|
|
∂x |
|
2 x |
|
|
I |
= |
∂I |
= |
I (x,y+ y,z)−I (x,y− y,z) . |
(11.4) |
|
∂y |
2 y |
|
|||
|
|
|
∂I |
|
I (x,y,z+ z)−I (x,y,z− z) |
|
|
|
|
|
|
|
|
|
|
|
∂z |
|
2 z |
|
The normal is calculated as n = | II | and the interaction of the light with each voxel is calculated during composition.
11.3.3 Summary
This section illustrated how some of the techniques described in this book can be applied to medical imaging data. Bear in mind the message from the previous section about limitations of the original images. If there is one message to take from surfaces from medical images, it is that they can be rather low quality, with discretization (‘staircase’ artifacts), holes, missing parts, foldovers and so on. On the other hand, the number of triangles in a triangulated surface can be huge and feel unnecessary with regards to graphics requirements, but one has to be very careful when smoothing or performing other manipulations. In medical imaging, the clinician may not be interested in final image quality, but might want to focus on small imperfections or other nearly indistinguishable features that could be indicative of disease. Medical diagnosis is inherently different from computer graphics in this respect. Volume rendering has the nice property that the voxel data is rendered without